FRED Optimizer tips & helps

Installing and running

The Optimizer lives under git.

Download using

git clone http://XXXuser@arpg-serv.ing2.uniroma1.it:8181/git/Optimizer.git 

where you need to replace XXXuser with the account under the git server (if you don't know if you have an account, ask a.sarti) and compile it as it is explained inside README.txt

To run the optimizer one has to launch it using the syntax

./optiRoot #inputfile

A template for the input file that uses 7 different fields can be found in the folder inpFiles.

The input file

The input files contains several fields and lines to setup the optimizer:

• The dij for each field can be specified using dij:
• ptv: defines what is the PTV and the goal dose, the weight
• oar: for the organs at risk one can set the max dose, the weight and the DMF.
• NoT: for the normal tissues (CT - PTV - OARs) one can set the max dose, the weight, the DMF and the threshold applied to consider the voxels as NoT
• outFlag: flags the output files

dij: SingleFieldMatrix/70MeV/Dij_merge1.bin
dij: SingleFieldMatrix/70MeV/Dij_merge2.bin
dij: SingleFieldMatrix/70MeV/Dij_merge3.bin
dij: SingleFieldMatrix/70MeV/Dij_merge4.bin
dij: SingleFieldMatrix/70MeV/Dij_merge5.bin
dij: SingleFieldMatrix/70MeV/Dij_merge6.bin
dij: SingleFieldMatrix/70MeV/Dij_merge7.bin
ptv: PTVTrue_NEW_itk.mhd Dgoal 2
oar: vescica_NEW_itk.mhd maxDose 2.2 DMF 1. weight 20 
oar: retto_NEW_itk.mhd maxDose 2.2 DMF 1. weight 20 
oar: bulbopenieno_NEW_itk.mhd maxDose 2.2 DMF 1. weight 20 
oar: femoredx_NEW_itk.mhd maxDose 1. DMF 1. weight 20 
oar: femoresin_NEW_itk.mhd maxDose 1. DMF 1. weight 20 
oar: ano_NEW_itk.mhd maxDose 2.2 DMF 1. weight 20 
NoT: maxDose 1.2 DMF 1. weight 10 thre 5.
outFlag: 70MeV_VeReBp22Gy_NT12_DMF1_OAR20

The new workflow

- legge il DMF_NT (default = 1)
- carica i PTV con relativa plannedDose ed eventuale DMF (default = 1)
- carica gli OAR con relativa maxDose ed eventuale DMF (default = 1)
- crea la mappa “dense” del DMF (per ogni voxel della CT)
- carica le varie Dij (ad esempio una per ogni field) applicando il DMF

- output: scrive la mappa con i voxel appartenenti alle varie ROI => rois.mhd
- output: scrive la mappa densa con il DMF delle varie ROI => alldmf.mhd

- lancia l’ottimizzatore

- output: ricostruisce e scrive la mappa di dose ottimizzata (usando il DMF) => optiDose.mhd

Checking the output

Creating the DVHs and analysing the output

In order to generate the DVH a script is provided by git.

To run it:

./testDVH/mhd_DVH.py -p -v -roi PTVTrue_NEW_itk.mhd vescica_NEW_itk.mhd retto_NEW_itk.mhd bulbopenieno_NEW_itk.mhd ano_NEW_itk.mhd femoredx_NEW_itk.mhd femoresin_NEW_itk.mhd -dose optiDose_70MeV_0.8Op_PTV_2GyVesRet_1Gyall.mhd --norm-volume -Dgoal 200

The available options can be prompted using

./testDVH/mhd_DVH.py -h

The output is.

-- Alessio Sarti - 2020-10-06

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